Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults
While higher CRF was significantly associated with greater total hippocampal volume, CRF was not associated with all underlying subfield volumes. Our results further demonstrate the relevance of the associations between CRF and hippocampal volume for episodic memory performance. Finally, our results suggest that the regionally-specific effects of aging and Alzheimer's disease on hippocampal subfields could be mitigated by maintaining higher CRF in older adulthood.
Authors
- Bradley P. Sutton (ORCID: https://orcid.org/0000-0002-8443-0408)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- George Grove (ORCID: https://orcid.org/0000-0002-5043-139X)
- Arthur Kramer (ORCID: https://orcid.org/0000-0002-1991-5046)
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Edward McAuley (ORCID: https://orcid.org/0000-0002-4574-3292)
- Audrey M. Collins
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Alina Lesnovskaya (ORCID: https://orcid.org/0000-0003-0406-4661)
- John M. Jakicic (ORCID: https://orcid.org/0000-0001-6800-9368)
- Charles H. Hillman (ORCID: https://orcid.org/0000-0002-3722-5612)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Rebecca G. Reed (ORCID: https://orcid.org/0000-0003-0794-594X)
- Sarah L. Aghjayan (ORCID: https://orcid.org/0000-0002-8597-2022)
- Haiqing Huang (ORCID: https://orcid.org/0000-0002-8932-7995)
- Hayley S. Ripperger
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Lu Wan (ORCID: https://orcid.org/0000-0001-8939-3004)
Institutions
- Northeastern University (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Cornell University (US)
- AdventHealth Orlando (US)
- Center for the Neural Basis of Cognition (US)
- University of Kansas Medical Center (US)
- Weill Cornell Medicine (US)
- Carnegie Mellon University (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fnagi.2024.1466328
- Citations
- 3
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- National Institutes of Health