ZFP36 expression profiles in breast tumors of different stages and hormonal receptor status

ZFP36 is a gene which is downregulated in various malignancies, and its expression level is often considered as a potential prognostic and diagnostic mar ker.Aim.In current study we investigated how the ZFP36 expression varies in breast tumors of different histological types, grades, metastatic status, as well as in tumors with different progesterone and human EGFR receptor 2 (HER2) status to assess its use as a potential breast cancer biomarker.Methods.RT-qPCR.Results.We show that the ZFP36 expression is elevated in T1-2 and N0-N1 tumors compared to adjacent tissues and T3-4 and N2 tumors, respectively.We also show that the ZFP36 expression does not vary in samples with different PR status, but significantly increases with HER2 amplification.Conclusions.The ZFP36 gene is a promising candidate to the HER2-enriched breast cancer biomarker, although further studies are necessary for verification.