Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway
This study demonstrates that depressed hepatic TFAM plays a key role in the pathogenesis of AILI, which is regulated by the DDX3X-PGC1α-NRF2 signaling pathway.
Authors
- Linlin Wei (ORCID: https://orcid.org/0000-0002-2958-5925)
- Yaling Cao (ORCID: https://orcid.org/0000-0002-4952-0643)
- Feng Ren (ORCID: https://orcid.org/0000-0001-7736-8637)
- Yao Gao (ORCID: https://orcid.org/0000-0002-6051-6004)
- Zihao Fan (ORCID: https://orcid.org/0000-0003-0011-8394)
- Ling Xu (ORCID: https://orcid.org/0000-0001-8446-4045)
- Mei Liu (ORCID: https://orcid.org/0000-0001-8513-1402)
- Sisi Chen (ORCID: https://orcid.org/0000-0002-1908-5054)
- Qiaoxin Wei
- Yuan Tian (ORCID: https://orcid.org/0009-0006-3773-8131)
- Xiangying Zhang (ORCID: https://orcid.org/0009-0004-7878-8560)
- Zhenzhen Pan
Institutions
- Capital Medical University (CN)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s10020-024-01017-0
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- National Natural Science Foundation of China