Alzheimer's disease‐associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain
Cross-tissue interaction between HCMV and the adaptive immune response in a subset of persons with AD. Presence of CD83(+) microglial associated with IgG4 and HCMV in the gut. CD83(+) microglia are also associated presence of HCMV and IgG4 in the cortex and vagal nerve. Replication of key association in an independent cohort of AD subjects. HCMV infection of cerebral organoids accelerates the production of AD neuropathological features.
Authors
- Camila de Ávila (ORCID: https://orcid.org/0000-0003-1067-5952)
- Yingleong Chan (ORCID: https://orcid.org/0000-0003-4474-6114)
- Jennifer Nolz
- Jean‐Vianney Haure‐Mirande (ORCID: https://orcid.org/0000-0002-5748-9666)
- Jacqueline Proszynski
- Winnie S. Liang (ORCID: https://orcid.org/0000-0002-5698-7735)
- Kendall R. Van Keuren‐Jensen (ORCID: https://orcid.org/0000-0001-8833-6323)
- Khanh V. Tran (ORCID: https://orcid.org/0000-0002-0121-6212)
- Eric B. Alsop (ORCID: https://orcid.org/0000-0002-2717-7573)
- Nathaniel Barton (ORCID: https://orcid.org/0000-0002-0383-7741)
- Deena Najjar (ORCID: https://orcid.org/0009-0009-7950-2866)
- Benjamin Readhead
- Adrian R. Orszulak (ORCID: https://orcid.org/0000-0003-2358-5702)
- Rebecca Reiman
- Joel T. Dudley (ORCID: https://orcid.org/0000-0002-7036-6492)
- Michael Jhatro (ORCID: https://orcid.org/0000-0002-6694-9679)
- Kristina E. Atanasoff
- John Shon (ORCID: https://orcid.org/0000-0001-9465-6286)
- Timothy F. Kowalik (ORCID: https://orcid.org/0000-0001-6096-3018)
- Geidy E. Serrano (ORCID: https://orcid.org/0000-0002-9527-2011)
- Krista Ryon (ORCID: https://orcid.org/0000-0001-9440-2729)
- Domenico Tortorella (ORCID: https://orcid.org/0000-0003-0961-3535)
- Diego Mastroeni (ORCID: https://orcid.org/0000-0001-5878-9372)
- Michelle E. Ehrlich (ORCID: https://orcid.org/0000-0001-9397-686X)
- Crystal Suazo (ORCID: https://orcid.org/0000-0003-4168-8924)
- Maria A. Sierra (ORCID: https://orcid.org/0000-0003-4115-034X)
- Jerry Antone
- Sean Liu (ORCID: https://orcid.org/0000-0002-3842-6838)
- Anne M. Mirza
- Kathy Kamath (ORCID: https://orcid.org/0000-0001-6143-3414)
- Rebecca L. Best (ORCID: https://orcid.org/0000-0001-7183-879X)
- Elaine T. Lim (ORCID: https://orcid.org/0000-0003-3651-0654)
- Christopher E. Mason (ORCID: https://orcid.org/0000-0002-1850-1642)
- Cory C. Funk (ORCID: https://orcid.org/0000-0002-5229-9011)
- Samantha M. Chigas (ORCID: https://orcid.org/0000-0003-1477-021X)
- Thomas G. Beach
- Qi Wang (ORCID: https://orcid.org/0000-0001-7626-676X)
- Sam Gandy (ORCID: https://orcid.org/0000-0001-6455-4721)
- David A. Bennett
- Eric M. Reiman
- Tajudeen O. Jimoh (ORCID: https://orcid.org/0000-0001-5713-6580)
Institutions
- Alzheimer's Association (US)
- Translational Genomics Research Institute (US)
- Rush University Medical Center (US)
- University of Massachusetts Chan Medical School (US)
- Cornell University (US)
- Institute for Systems Biology (US)
- Serimmune (United States) (US)
- Banner Sun Health Research Institute (US)
- Banner Alzheimer’s Institute
- Weill Cornell Medicine (US)
- Arizona State University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1002/alz.14401
- Citations
- 14
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.46
Funders
- Arizona Department of Health Services
- Global Lyme Alliance
- Benter Foundation
- NOMIS Stiftung
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke