Chitosan-Based Nanocapsules as a Delivery System of Hydrophobic Carnosic Acid, A Model Neuroprotective Drug
The capsules with diameters between 90 and 150 nm and long-term stability were obtained. Cytotoxicity tests of empty capsules indicate that observed toxic effects were concentration dependent and lower concentrations (dilution above 500×) can be considered as safe for tested cells. Our study also indicates that encapsulation of carnosic acid decreased the cytotoxicity of empty nanocapsules and can efficiently protect SH-SY5Y cells from factors causing cell destruction. In addition, the neuroprotective efficacy of carnosic acid loaded nanocapsules was also demonstrated in SH-SY5Y cells exposed to toxic concentration of H<sub>2</sub>O<sub>2</sub>. The designed nanoparticles appear to possess sufficient biocompatibility to deserve their further evaluation in in vivo models.
Authors
- Magdalena Regulska (ORCID: https://orcid.org/0000-0003-2683-0654)
- Dorota Duraczyńska (ORCID: https://orcid.org/0000-0002-4721-1417)
- Joanna Odrobińska (ORCID: https://orcid.org/0000-0002-5941-4107)
- Szczepan Zapotoczny (ORCID: https://orcid.org/0000-0001-6662-7621)
- Magdalena Procner (ORCID: https://orcid.org/0000-0002-1185-0305)
- Krzysztof Szczepanowicz (ORCID: https://orcid.org/0000-0002-9927-5869)
- Władysław Lasoń
- Monika Leśkiewicz (ORCID: https://orcid.org/0000-0001-7261-2821)
- Kinga Krużel
Institutions
- Jagiellonian University (PL)
- Maj Institute of Pharmacology (PL)
- Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences (PL)
Publication Details
- Journal
- Nanotechnology Science and Applications
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/nsa.s490372
- Citations
- 6
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48