Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis
In conclusion, folic acid supplementation prior to and throughout pregnancy exerts preventive effects on high-fat diet-induced PPWR in rats, and the mechanism is associated with the inhibition of ER stress-mediated lipogenesis signaling pathways in the liver. Folic acid supplementation may serve as a potential strategy for preventing PPWR. In the future, the effectiveness of folic acid in PPWR prevention can be further verified by population studies.
Authors
- Yanzhen Ma (ORCID: https://orcid.org/0000-0003-4578-6839)
- Hui Liang (ORCID: https://orcid.org/0000-0002-0675-6963)
- Xuenuo Zhao
- Zhihong Zhang (ORCID: https://orcid.org/0000-0003-4458-1065)
- Li Zhang (ORCID: https://orcid.org/0000-0001-6061-6833)
- Dan Sun (ORCID: https://orcid.org/0000-0002-2833-3806)
- Xi Liang (ORCID: https://orcid.org/0009-0009-5376-1456)
- Weiheng Liu
- Yixian Bai
Institutions
- Qingdao University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3390/nu16244377
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province