Photocatalytic <i>E</i> → <i>Z</i> isomerization of <i>gem</i>-bromofluoroalkenes: stereoselective synthesis of β-fluorostyrene derivatives
Stereoselective synthesis of β-fluorostyrene derivatives has been achieved. Selective isomerization of <i>gem</i>-bromofluoroalkenyl benzenes bearing various <i>ortho</i>-substituents is enabled by using Ir photocatalysts with high triplet energy. Subsequent one-pot transition-metal (TM)-catalyzed reactions enable pot-economical synthesis of monofluoroalkenes in a stereoselective manner.
Authors
- Hiroshi Kato (ORCID: https://orcid.org/0000-0003-0807-1375)
- Yoshihito Kayaki (ORCID: https://orcid.org/0000-0002-4685-8833)
- Takashi Koike (ORCID: https://orcid.org/0000-0002-3737-7093)
Institutions
- Tokyo Institute of Technology (JP)
- Nippon Institute of Technology (JP)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1039/d4ob01658k
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Science and Technology Corporation
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science