Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing
Our results showed that VECs are highly heterogeneous in a side- and CAVD-dependent manner. Unique VEC clusters and their differentially regulated genes and pathways found in the fibrosa of diseased tissues may represent novel pathogenic mechanisms and potential therapeutic targets.
Authors
- Kyung In Baek (ORCID: https://orcid.org/0000-0001-9388-2070)
- Aitor Andueza (ORCID: https://orcid.org/0000-0002-6501-3035)
- Hanjoong Jo (ORCID: https://orcid.org/0000-0003-1833-372X)
- Mark C. Blaser (ORCID: https://orcid.org/0000-0002-3923-9786)
- Nicolas Villa-Roel (ORCID: https://orcid.org/0000-0002-2981-9330)
- C.-S. Park (ORCID: https://orcid.org/0000-0002-3975-1202)
- Elena Aïkawa (ORCID: https://orcid.org/0000-0001-7835-2135)
- Ally J. Su (ORCID: https://orcid.org/0000-0001-6447-3438)
- Bradley G. Leshnower (ORCID: https://orcid.org/0000-0002-2290-1729)
- Ajit P. Yoganathan (ORCID: https://orcid.org/0000-0001-5818-1316)
Institutions
- Brigham and Women's Hospital (US)
- Georgia Institute of Technology (US)
- Harvard University (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- Genes
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3390/genes15121623
- Citations
- 7
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Emory University
- National Institutes of Health
- Winship Cancer Institute
- National Cancer Institute