<scp>STING</scp> Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis‐Associated Encephalopathy in Mice
Sepsis-induced STING overexpression in microglia/macrophages may lead to synaptic loss, abnormal theta oscillation and LTP impairment through microglia/macrophages activation and complement C1q modulation, ultimately resulting in cognitive impairment.
Authors
- Xin Lv (ORCID: https://orcid.org/0009-0000-9569-1091)
- Mu‐Huo Ji (ORCID: https://orcid.org/0000-0003-4944-6436)
- Jin-Chun Shen (ORCID: https://orcid.org/0000-0002-9529-7796)
- Jianjun Yang (ORCID: https://orcid.org/0000-0001-6785-9627)
- Jinlong Jian (ORCID: https://orcid.org/0000-0002-7008-9659)
- Yugang Diao (ORCID: https://orcid.org/0000-0003-4509-9035)
- Min Jia (ORCID: https://orcid.org/0000-0002-5452-5756)
- Daqing Ma (ORCID: https://orcid.org/0000-0003-1235-0537)
- Feng Xiao (ORCID: https://orcid.org/0000-0002-7895-7940)
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Children's Hospital of Zhejiang University (CN)
- General Hospital of Shenyang Military Region (CN)
- Chelsea and Westminster Hospital (GB)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Imperial College London (GB)
- Nanjing University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70166
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Imperial College London
- National Natural Science Foundation of China
- Zhengzhou University
- Nanjing University
- First Affiliated Hospital of Zhengzhou University