Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome
Despite children with DS exhibiting lower cognitive skills and smaller brain volume overall than children with ASD, their deficits in Socialization and Daily Living adaptive skills are comparable. Differences in lobar volumes (e.g., Right Frontal GM/WM, Left Frontal WM, and Left and Right Temporal WM) were observed above and beyond overall differences in total volume. The correlation between cerebellum volumes and Daily Living adaptive behaviors in the DS group provides a novel area to explore in future research.
Authors
- D. L. Collins
- Jed T. Elison (ORCID: https://orcid.org/0000-0002-6246-1000)
- Guido Gerig (ORCID: https://orcid.org/0000-0002-9547-6233)
- Vladimir Fonov (ORCID: https://orcid.org/0000-0003-3402-7749)
- Jessica B. Girault (ORCID: https://orcid.org/0000-0002-9271-0354)
- Natasha Marrus (ORCID: https://orcid.org/0000-0001-6521-0373)
- K. Truong
- Juhi Pandey
- Stephen R. Dager (ORCID: https://orcid.org/0000-0002-4034-6087)
- Audrey M. Shen
- Rebecca Grzadzinski (ORCID: https://orcid.org/0000-0001-7764-6166)
- Kelly N. Botteron (ORCID: https://orcid.org/0000-0001-5276-9653)
- Jason J. Wolff (ORCID: https://orcid.org/0000-0003-4300-8195)
- Daniel J. Shaw (ORCID: https://orcid.org/0000-0003-1139-8301)
- Mark D. Shen (ORCID: https://orcid.org/0000-0002-1190-7981)
- Robert T. Schultz
- Tanya St. John (ORCID: https://orcid.org/0000-0003-2448-5797)
- Dea Garic (ORCID: https://orcid.org/0000-0003-3595-4210)
- Robert C. McKinstry (ORCID: https://orcid.org/0000-0003-3578-4899)
- Heather C. Hazlett (ORCID: https://orcid.org/0000-0001-9166-1434)
- Martin Andreas Styner (ORCID: https://orcid.org/0000-0002-8747-5118)
- Annette Estes (ORCID: https://orcid.org/0000-0003-2687-4155)
- Samir Das (ORCID: https://orcid.org/0000-0003-2018-8760)
- Leigh MacIntyre
- Alapika Jatkar (ORCID: https://orcid.org/0000-0001-6899-736X)
- J. Constantino
- Ami Siddharth Bhatt (ORCID: https://orcid.org/0000-0001-8099-2975)
- Heather E. Volk (ORCID: https://orcid.org/0000-0002-5415-2494)
- Sun Hyung Kim (ORCID: https://orcid.org/0000-0003-4007-9385)
- Lonnie Zwaigenbaum
- Alan Evans
- Dani Fallin
- Joseph Piven
- J. R. Pruett
- C. Chappell
- Kattia Mata
Institutions
- University of North Carolina at Chapel Hill (US)
- Montreal Neurological Institute and Hospital (CA)
- Children's Hospital of Philadelphia (US)
- University of Alberta (CA)
- University of Washington (US)
- Washington University in St. Louis (US)
- New England College of Optometry (US)
- Easterseals (US)
- Mallinckrodt (United States) (US)
- Carolina Institute for NanoMedicine (US)
- McGill University (CA)
- New York University (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s11689-024-09581-6
- Citations
- 3
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Children's Hospital of Philadelphia
- University of Minnesota
- Washington University in St. Louis
- University of Washington
- Johns Hopkins University
- York University
- University of Alberta
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development