Four functional genotoxic marker genes (Bax, Btg2, Ccng1, and Cdkn1a) discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens and non-genotoxic non-hepatocarcinogens in rat public toxicogenomics data, Open TG-GATEs
The present results unequivocally demonstrate the availability of four genotoxic marker genes ((Bax, Btg2, Ccng1, and Cdkn1a) and PCA in discriminating GTHCs from NGTHCs and NGTNHCs in Open TG-GATEs. These findings strongly support our recommendation that future rat liver in vivo toxicogenomics tests prioritize these four genotoxic marker genes, as they have proven to be highly effective in discriminating between different types of hepatocarcinogens.
Authors
- Chie Furihata (ORCID: https://orcid.org/0000-0003-0533-1469)
- Takayoshi Suzuki (ORCID: https://orcid.org/0000-0002-2261-5263)
Institutions
- Aoyama Gakuin University (JP)
- National Institute of Health Sciences (JP)
Publication Details
- Journal
- Genes and Environment
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s41021-024-00322-8
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00