Single-cell RNA sequencing reveals the contribution of smooth muscle cells and endothelial cells to fibrosis in human atrial tissue with atrial fibrillation
This study provides a cellular landscape based on the atrial tissue of patients with AF and highlights intercellular changes and differentially expressed genes that occur during the disease process. A thorough description of the cellular populations involved in AF will facilitate the identification of new cell-based interventional targets with direct functional significance for the treatment of human disease.
Authors
- Yanwei Xing (ORCID: https://orcid.org/0000-0002-1392-9738)
- Yonghong Gao (ORCID: https://orcid.org/0000-0002-3771-3528)
- Yuchen Jiang (ORCID: https://orcid.org/0000-0003-4660-7847)
- Hongcai Shang
- Peifeng Ji (ORCID: https://orcid.org/0000-0001-6380-7416)
- Na An (ORCID: https://orcid.org/0000-0001-7794-2539)
- Guoxia Zhang (ORCID: https://orcid.org/0000-0003-2530-3238)
- Fan Yang (ORCID: https://orcid.org/0000-0001-7809-8288)
- Yingjian Li (ORCID: https://orcid.org/0009-0000-9869-014X)
- Haoqi Liu (ORCID: https://orcid.org/0000-0002-0374-0456)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Institute of Genomics (CN)
- Beijing Anzhen Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s10020-024-00999-1
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences
- National Key Research and Development Program of China