Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures
Hypertriglyceridemic <i>Apoc2</i> <sup>-/-</sup> hamsters exhibited reduced seizure frequency and decreased cortical neuron excitability. The upregulation of ZDHHC14, leading to increased I<sub>A</sub>, may be a crucial mechanism underlying the observed seizure protection.
Authors
- Xinlin Hou (ORCID: https://orcid.org/0000-0002-4412-5492)
- Qiuyue Shen (ORCID: https://orcid.org/0009-0008-9890-4185)
- Yuwu Jiang (ORCID: https://orcid.org/0000-0002-5179-9807)
- Lili Liu (ORCID: https://orcid.org/0000-0003-2509-2362)
- Nana Liu (ORCID: https://orcid.org/0000-0002-0135-3575)
Institutions
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Chinese Institute for Brain Research (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fneur.2024.1500737
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- National Natural Science Foundation of China
- Peking University
- National Key Research and Development Program of China