<i>In vitro</i> activity and genomic characterization of KPC-producing <i>Klebsiella pneumoniae</i> clinical blood culture isolates resistant to ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam: an Italian nationwide multicentre obse
New BLICs were shown to be the most widely active therapeutic option against KPC-Kp clinical isolates collected in Italy. Ceftazidime/avibactam resistance is mainly driven by the expression of KPC variants, whereas the loss of function of the OmpK35 and OmpK36 porins appears to play a key but not exclusive role in the development of meropenem/vaborbactam and/or imipenem/relebactam resistance.
Authors
- Guido Antonelli (ORCID: https://orcid.org/0000-0002-2533-2939)
- Gabriele Bianco (ORCID: https://orcid.org/0000-0002-8180-5075)
- Rossana Cavallo (ORCID: https://orcid.org/0000-0001-8655-8707)
- Rita Greco (ORCID: https://orcid.org/0000-0003-4164-8578)
- Paolo Gaibani (ORCID: https://orcid.org/0000-0003-3791-8635)
- Federica Sacco (ORCID: https://orcid.org/0000-0001-7933-8407)
- Claudio Farina (ORCID: https://orcid.org/0000-0003-2298-4293)
- Matteo Boattini (ORCID: https://orcid.org/0000-0001-6726-2716)
- Sofia Chiatamone Ranieri (ORCID: https://orcid.org/0000-0003-3151-5894)
- Simone Ambretti (ORCID: https://orcid.org/0000-0002-8358-339X)
- Annarita Mazzariol (ORCID: https://orcid.org/0000-0003-2729-1007)
- Bianca Paglietti (ORCID: https://orcid.org/0000-0002-2568-0642)
- Francesco Broccolo (ORCID: https://orcid.org/0000-0002-9737-0459)
- Maura Fiamma (ORCID: https://orcid.org/0000-0002-9908-3461)
- Linda Degl’Innocenti
- Teresa Fasciana (ORCID: https://orcid.org/0000-0003-4073-5813)
- Cristina Costa (ORCID: https://orcid.org/0000-0002-6549-4553)
- Laura Isabella Lupo (ORCID: https://orcid.org/0000-0003-3738-4928)
- Davide Gibellini (ORCID: https://orcid.org/0000-0003-3688-1252)
- Sara Comini
- Angela Quirino
Institutions
- University of Verona (IT)
- University of Teramo (IT)
- University of Salento (IT)
- University of Sassari (IT)
- Policlinico Umberto I (IT)
- Magna Graecia University (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Antonio Cardarelli (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Ospedale Papa Giovanni XXIII (IT)
- ATS Sardegna (Italy) (IT)
- Azienda USL di Bologna (IT)
- Department of Medical Sciences (BY)
- Ospedale Vito Fazzi (IT)
- Carlo Forlanini Hospital (IT)
- University of Turin (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1093/jac/dkae450
- Citations
- 12
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.04