Distinguishing Daratumumab from Endogenous Monoclonal Proteins in Serum from Multiple Myeloma Patients Using an Automated Mass Spectrometry System
The Immunoglobulin Isotypes (GAM: IgG, IgA, and IgM) for the EXENT Analyzer detected and distinguished a daratumumab kappa light chain peak from an M-protein light chain peak in MM patient serum when resolved by the mass spectrometer.
Authors
- Gabriella Lakos (ORCID: https://orcid.org/0000-0003-2856-3617)
- David R. Barnidge (ORCID: https://orcid.org/0000-0002-3314-8293)
- Tadeusz Kubicki (ORCID: https://orcid.org/0000-0001-7588-1453)
- Andrzej J. Jakubowiak (ORCID: https://orcid.org/0000-0002-2597-6822)
- Benjamin Avi Derman (ORCID: https://orcid.org/0000-0002-4070-1819)
- Dhananjay Sakrikar (ORCID: https://orcid.org/0000-0001-8430-0120)
Institutions
- University of Chicago (US)
- Thermo Fisher Scientific (United States) (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1093/jalm/jfae142
- Citations
- 7
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.18