A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon
Two major cytokinesis mechanisms, rooted in contractile FtsZ and endosomal sorting complexes required for transport (ESCRT) rings, respectively, have emerged in the course of evolution. Whereas bacteria rely on the FtsZ-based mechanism, different lineages of archaea use either of the two systems, and eukaryotes have inherited the ESCRT-based cell division machinery from their archaeal ancestors. The mechanism of ESCRT-based cell division in archaea remains poorly understood and mechanistic studies on different archaeal model systems are essential to unravel the natural history of the ESCRT machinery. Here we investigate the interplay between three major ESCRT-III homologs during the division of a hyperthermophilic archaeon <i>Saccharolobus islandicus</i> and propose the "relay race" model of cytokinesis.
Authors
- Audrey Salles (ORCID: https://orcid.org/0000-0002-1890-6957)
- Mart Krupovìč (ORCID: https://orcid.org/0000-0001-5486-0098)
- Mickaël Lelek (ORCID: https://orcid.org/0000-0003-4881-3847)
- Yulong Shen (ORCID: https://orcid.org/0000-0003-3566-0466)
- Christophe Zimmer (ORCID: https://orcid.org/0000-0001-9910-1589)
- Yunfeng Yang (ORCID: https://orcid.org/0009-0009-6265-2761)
- Junfeng Liu (ORCID: https://orcid.org/0009-0009-7133-3367)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Shandong University (CN)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- University of Würzburg (DE)
- Ecologie microbienne (FR)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- mBio
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1128/mbio.00991-24
- Citations
- 13
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- Agence Nationale de la Recherche
- National Natural Science Foundation of China
- National Key Research and Development Program of China