SARS-CoV-2 S protein disrupts the formation of ISGF3 complex through conserved S2 subunit to antagonize type I interferon response
This study unveils a new mechanism by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein attenuates the host's antiviral immune response. The interferon-inhibitory mechanism of the S protein was universal among SARS-CoV-2 variants and other human coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, and HCoV-HKU1, through conserved S2 domains. Our study expands the understanding of SARS-CoV-2 and other human coronaviruses in evading antiviral immune strategies, which is very important for the design and optimization of vaccine antigens, thus providing a theoretical basis for human anti-coronavirus immunity and understanding the interaction between the host and coronavirus.
Authors
- Wenkang Li (ORCID: https://orcid.org/0000-0002-1131-9282)
- Yu Chen (ORCID: https://orcid.org/0000-0003-1300-4652)
- Xiaoqian Yao (ORCID: https://orcid.org/0000-0001-7624-3883)
- Weifeng Yuan (ORCID: https://orcid.org/0000-0001-8336-6822)
- Wenjia Ni (ORCID: https://orcid.org/0009-0000-6763-5391)
- Simeng Liang (ORCID: https://orcid.org/0000-0002-4698-9374)
- Mingliang Tang (ORCID: https://orcid.org/0000-0002-6182-8202)
- Ke Lan (ORCID: https://orcid.org/0000-0002-0384-8598)
- Yongliang Zhao (ORCID: https://orcid.org/0000-0001-7018-6582)
- Zhixuan Wu (ORCID: https://orcid.org/0000-0003-2639-9083)
- Li Zhou (ORCID: https://orcid.org/0000-0002-6736-0057)
- Ke Xu (ORCID: https://orcid.org/0000-0002-3454-8993)
- Zeng Cai (ORCID: https://orcid.org/0000-0001-5398-7193)
- Yucheng Zheng (ORCID: https://orcid.org/0009-0003-1030-5553)
- Qi Wang (ORCID: https://orcid.org/0000-0003-0962-4218)
Institutions
- Chengdu Medical College (CN)
- Wuhan University (CN)
- State Key Laboratory of Virology
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1128/jvi.01516-24
- Citations
- 11
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 2.65
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Wuhan University
- Fundamental Research Funds for the Central Universities