Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway
This study identifies denatonium as an inhibitor of RANKL-induced osteoclast differentiation, potentially acting through suppression of the p65 signaling pathway. The ability of denatonium to downregulate osteoclast-related genes and inhibit key signaling events highlights its potential as a candidate for further investigation in the context of bone loss and osteoporosis.
Authors
- Jin Sook Song (ORCID: https://orcid.org/0000-0001-8023-7769)
- Kyubin Lee (ORCID: https://orcid.org/0000-0002-9445-2838)
- You-Jee Jang (ORCID: https://orcid.org/0000-0003-0377-3490)
- Sunyou Park
- Tae Kyung Hyun (ORCID: https://orcid.org/0000-0003-4930-4956)
- Sheunghun Lee
- Ji Hoon Lee (ORCID: https://orcid.org/0000-0002-8118-861X)
- Jin‐Man Kim (ORCID: https://orcid.org/0000-0003-0905-9730)
- Kyunghwan Kim (ORCID: https://orcid.org/0000-0001-5622-2452)
- Hye‐Jung Kim (ORCID: https://orcid.org/0000-0003-1529-8930)
- Hye-Rim Lee (ORCID: https://orcid.org/0000-0002-9495-2701)
- Jae-Il Park (ORCID: https://orcid.org/0000-0001-8148-290X)
- Sun-Ju Yi (ORCID: https://orcid.org/0009-0000-3323-0222)
- Jung Yeol Lee
Institutions
- Chonnam National University (KR)
- Chungbuk National University (KR)
- Honam University (KR)
- Asan Medical Center (KR)
- Korea Basic Science Institute (KR)
- Korea Research Institute of Chemical Technology (KR)
- Osong Medical Innovation Foundation (KR)
- Daegu-Gyeongbuk Medical Innovation Foundation (KR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s10020-024-01031-2
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Research Foundation
- Chungbuk National University
- National Research Foundation of Korea