Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression
scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links between LCE and LAMP5 overexpression to osteolysis and prognosis, validated in RNA-seq databases.
Authors
- Zachary J. Walker (ORCID: https://orcid.org/0009-0002-1384-3309)
- Lorraine N. Davis (ORCID: https://orcid.org/0000-0001-9624-4752)
- Krysta L. Engel (ORCID: https://orcid.org/0000-0003-3132-1491)
- Denis Ohlstrom (ORCID: https://orcid.org/0000-0003-1920-6319)
- Daniel W. Sherbenou (ORCID: https://orcid.org/0000-0003-3013-7174)
- Peter A. Forsberg (ORCID: https://orcid.org/0000-0003-3248-7530)
- Tomer M. Mark (ORCID: https://orcid.org/0000-0001-6996-0497)
- Zenggang Pan (ORCID: https://orcid.org/0000-0003-4537-3356)
- Austin E. Gillen (ORCID: https://orcid.org/0000-0003-2928-6308)
- Abhishek Pandey
Institutions
- Georgia Institute of Technology (US)
- University of Colorado Cancer Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0170
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.45