The phenomenon of the BRAF and TERTp mutational duet in melanoma and other cancers
The unique oncogenic duo of BRAF and TERT promoter ( TERT p) variants was demonstrated to be associated with aggressiveness and poor prognosis in several different cancer types, including melanoma and thyroid cancer. It has been shown that the coexistence of BRAF and TERT p variants has a significantly more substantial impact on clinical outcomes than the presence of mutated BRAF or TERT p alone. At the same time, the co-occurrence of BRAF and TERT p variants may also be the Achilles Heel of cancer cells in the context of targeted therapies’ effectiveness. This paper aims to summarize data from tumors in which clinically significant variants in BRAF and TERT p were documented as prognostic or predictive markers.
Authors
- Małgorzata Oczko‐Wojciechowska (ORCID: https://orcid.org/0000-0002-8989-0075)
- Dagmara Rusinek (ORCID: https://orcid.org/0000-0003-4115-3751)
- Anna Malgorzata Czarnecka (ORCID: https://orcid.org/0000-0002-2107-3810)
- Artur Zajkowicz (ORCID: https://orcid.org/0000-0002-7567-7118)
- Aleksandra Pfeifer (ORCID: https://orcid.org/0000-0002-0189-9711)
- Jolanta Pamuła‐Piłat (ORCID: https://orcid.org/0000-0002-6289-2329)
- Karolina Tęcza (ORCID: https://orcid.org/0000-0003-0204-6531)
Institutions
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
Publication Details
- Journal
- Nowotwory Journal of Oncology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.5603/njo.103026
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00