A visual scale to rate amygdalar atrophy on MRI
Question Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
Authors
- Francesca B. Pizzini (ORCID: https://orcid.org/0000-0002-6285-0989)
- Vittoria Rossi
- Max Scheffler
- Federica Ribaldi (ORCID: https://orcid.org/0000-0001-9208-4472)
- Giovanni B. Frisoni (ORCID: https://orcid.org/0000-0001-7075-7082)
- Valerio Natale
Institutions
- University of Geneva (CH)
- University of Verona (IT)
- Ospedale di Rivoli (IT)
- University Hospital of Geneva (CH)
Publication Details
- Journal
- European Radiology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1007/s00330-024-11249-7
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Science Foundation
- Alzheimer's Disease Neuroimaging Initiative
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Hôpitaux Universitaires de Genève
- Fondation Segré
- Horizon 2020 Framework Programme