Dynamic control of the plasmid copy number maintained without antibiotics in Escherichia coli
Our system offers a strategy to identify the optimal expression level of genes that have a competitive relationship with metabolic pathways crucial for the growth of the host organism. This approach can potentially be applied to other bacterial hosts by substituting the sensing module or the essential gene.
Authors
- Jina Yang (ORCID: https://orcid.org/0000-0001-5035-3283)
- Geunyung Park (ORCID: https://orcid.org/0000-0001-5326-9087)
- Sang Woo Seo (ORCID: https://orcid.org/0000-0002-7434-7053)
Institutions
- Seoul National University (KR)
- National University (SD)
- Jeju National University (KR)
Publication Details
- Journal
- Journal of Biological Engineering
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s13036-024-00460-1
- Citations
- 2
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- National Research Foundation
- National Research Foundation of Korea
- Korea Institute of Marine Science and Technology promotion
- Ministry of Science and ICT, South Korea