Synthesis, Molecular Docking Study, and Effect on the Methylation of Tumor DNA of Benzo[4′,5′]imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidines Functionalized by Aromatic Groups and Azines
6-Benzyl-4-styrylbenzo[4′,5′]imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidines and their conjugates with uracil, 5-fluorouracil, and 6-azauracile were synthesized. In addition to the previous findings, it was found that the reaction of 4-methyl-2-phenyl-5,6-dihydrobenzo[4′,5′]imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidine with aromatic aldehydes in acetic anhydride, depending on the nucleophilicity of the aldehyde carbonyl group, involved both C6H2 methylene group at the α-position with respect to the benzimidazole fragment and the 4-methyl group. The results of molecular docking study of the synthesized compounds and their effect on the methylation of tumor DNA are presented.
Authors
- H. А. Panosyan (ORCID: https://orcid.org/0000-0001-8311-6276)
- M. S. Safaryan (ORCID: https://orcid.org/0000-0003-2973-1088)
- S. G. Israelyan (ORCID: https://orcid.org/0009-0000-8088-1060)
- Artur A. Hambardzumyan (ORCID: https://orcid.org/0000-0001-9526-7768)
- A. S. Sargsyan (ORCID: https://orcid.org/0000-0001-7249-233X)
- R. E. Muradyan (ORCID: https://orcid.org/0000-0002-4110-9454)
- I. S. Danielyan (ORCID: https://orcid.org/0000-0003-0130-6653)
- A. S. Aharonyan (ORCID: https://orcid.org/0000-0001-7935-6867)
- А. А. Harutyunyan (ORCID: https://orcid.org/0000-0003-0641-5453)
- L. E. Nersesyan (ORCID: https://orcid.org/0000-0002-6738-5465)
- A. S. Sumbatyan (ORCID: https://orcid.org/0000-0001-8373-5130)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1134/s1070428024100051
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00