The Use of Nootropic Drugs to Reduce Toxic Reactions in Rats to a Combination of Anti-Tuberculosis Drugs

The objective: to evaluate the hepatoprotective and neuroprotective activity of the nootropic drug of deanol aceglumate (nooclerin) in rats during the administration of a hepatotoxic combination of anti-tuberculosis drugs. Subjects and Methods. Young non-linear female rats divided in 3 groups were used in this study. For 14 days, daily, rats from experimental Groups 1 and 2 received a regimen containing 5 anti-tuberculosis drugs: Mxf+ Lzd+ Cs+ Pto+ Z. Additionally, rats of Group 2 were injected with nooclerin before the administration of anti-tuberculosis drugs. Rats from Control Group received only starch suspension. Doses of anti-tuberculosis drugs and nooclerin corresponded to recommended doses for humans. The manifestation of neurotoxicity was assessed by changes in behavioral reactions according to Open Field Test, hepatotoxicity was assessed according to biochemical and morphological criteria. Results. The hepatoprotective effect of nooclerin was confirmed by statistically significant decrease in the transaminases and bilirubin activity, which elevation was caused by anti-tuberculosis drugs, and a significant (4-fold) decrease in the severity of pathological changes in the liver tissue. Studies of behavioral reactions showed that nooclerin slightly improved the exploratory activity of rats, which was slightly reduced under the influence of anti-tuberculosis drugs.