Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis
The absence of IL-6Rα in KO MGCs corresponded to significant changes in their proteomic profile, highlighting the impact of autocrine IL-6 signaling on MGC function. This study provides a basis for future research evaluating distinct roles of IL-6 in MGCs and subsequent effects on retinal pathology.
Authors
- Tae Jin Lee (ORCID: https://orcid.org/0000-0002-5245-1140)
- Ashok Sharma (ORCID: https://orcid.org/0000-0001-9597-4374)
- J. David Glass (ORCID: https://orcid.org/0009-0003-1575-2192)
- Neel Edupuganti
- Shruti Sharma (ORCID: https://orcid.org/0000-0001-8200-108X)
- Wenbo Zhi (ORCID: https://orcid.org/0000-0002-7720-7048)
- Rebekah Robinson (ORCID: https://orcid.org/0000-0001-9234-6209)
- Grace Greenway
- Jeremy Altman
Institutions
- Augusta University (US)
- Discovery Institute (US)
- Augusta University Health (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1167/iovs.65.14.33
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Augusta University
- National Institutes of Health