A constitutive heterochromatic region shapes genome organization and impacts gene expression in Neurospora crassa
Our work elucidates how an individual constitutive heterochromatic region impacts genome organization and function. Specifically, one silent region indirectly assists in the hierarchical folding of the entire Neurospora genome by aggregating into the "typical" heterochromatin bundle normally observed in wild type nuclei, which may promote normal gene expression by positioning euchromatin in the nucleus center.
Authors
- Oluwatosin Oluwadare (ORCID: https://orcid.org/0000-0002-5264-2342)
- Andrew T. Reckard (ORCID: https://orcid.org/0000-0003-2686-0183)
- Andrew D. Klocko (ORCID: https://orcid.org/0000-0002-2236-672X)
- Abhishek Pandeya
- Carlos G. Gonzalez Cruz
- Jacob M. Voris
Institutions
- University of Colorado Colorado Springs (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12864-024-11110-7
- Citations
- 3
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Science Foundation
- Colorado College
- University of Oregon
- National Institutes of Health