MRI-based prediction of microvascular invasion/high tumor grade and adjuvant therapy benefit for solitary HCC ≤ 5 cm: a multicenter cohort study
Question Despite being associated with increased recurrence and potential benefit from adjuvancy in HCC, microvascular invasion or Edmondson-Steiner grade 3/4 are hardly assessable noninvasively. Findings We developed and externally validated an MRI-based model for predicting high-risk histopathology, post-resection/ablation recurrence-free survival, and adjuvant therapy benefit in solitary HCC ≤ 5 cm. Clinical relevance Among patients receiving curative-intent resection or ablation for solitary HCC ≤ 5 cm, noninvasive identification of high-risk histopathology (MVI or high-grade) using our proposed MRI model may help improve individualized prognostication and patient selection for adjuvant therapies.
Authors
- Shenghong Ju (ORCID: https://orcid.org/0000-0001-5041-7865)
- Yuanan Wu (ORCID: https://orcid.org/0000-0003-4513-1357)
- Yun Qin (ORCID: https://orcid.org/0000-0002-8029-6547)
- Binrong Li
- Kathryn J. Fowler (ORCID: https://orcid.org/0000-0001-9188-1701)
- Hanyu Jiang (ORCID: https://orcid.org/0000-0002-7726-1618)
- Mustafa Rifaat Bashir (ORCID: https://orcid.org/0000-0001-8800-5057)
- Victoria Chernyak (ORCID: https://orcid.org/0000-0002-5715-1403)
- Bin Song (ORCID: https://orcid.org/0000-0002-7269-2101)
- Maxime Ronot (ORCID: https://orcid.org/0000-0001-7464-3939)
- Yuancheng Wang (ORCID: https://orcid.org/0000-0002-6253-8311)
- Zhenru Wu (ORCID: https://orcid.org/0000-0001-5974-8265)
- Weixia Chen (ORCID: https://orcid.org/0000-0003-1944-3066)
- Tianying Zheng
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Université Paris Cité (FR)
- Sichuan University (CN)
- Hôpital Beaujon (FR)
- University of California San Diego (US)
- West China Hospital of Sichuan University (CN)
- Assistance Publique – Hôpitaux de Paris (FR)
- Zhongda Hospital Southeast University (CN)
- Duke Medical Center (US)
- Sanya Central Hospital (CN)
- Southeast University (CN)
Publication Details
- Journal
- European Radiology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1007/s00330-024-11295-1
- Citations
- 5
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan University
- West China Hospital, Sichuan University