Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis
These findings suggest that WY-PEG-CeO exerts therapeutic effects in OA by inhibiting oxidative stress and suppressing the over-activation of PI3K/AKT and MAPK signaling pathways. This investigation served as a fundamental step towards the advancement of CeONPs-based interventions, providing potential strategies for the treatment of OA.
Authors
- Panghu Zhou (ORCID: https://orcid.org/0000-0002-7020-4258)
- Huajie Li (ORCID: https://orcid.org/0000-0002-1201-9863)
- Xunshan Ren
- Yuelong Zhang
- Huangming Zhuang (ORCID: https://orcid.org/0000-0001-6297-2030)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12951-024-03068-1
- Citations
- 16
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Wuhan University
- Fundamental Research Funds for the Central Universities
- Renmin Hospital of Wuhan University