Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial
Amino acid infusion protected chronic kidney disease patients undergoing cardiopulmonary bypass from developing acute kidney injury, with an absolute risk reduction of 7% and a number needed to treat of 14 in a cohort with a greater than 45% rate of acute kidney injury. Moreover, it delivered a greater than 50% relative risk reduction in severe acute kidney injury.
Authors
- Luca Brazzi (ORCID: https://orcid.org/0000-0001-7059-0622)
- Simona Silvetti (ORCID: https://orcid.org/0000-0002-3320-9228)
- Pasquale Mastroroberto
- Marco Ranucci (ORCID: https://orcid.org/0000-0002-4915-3572)
- Fabrizio Monaco (ORCID: https://orcid.org/0000-0001-5186-1976)
- Giovanni Serena (ORCID: https://orcid.org/0000-0001-7986-1150)
- Giovanni Landoni (ORCID: https://orcid.org/0000-0002-8594-5980)
- Antonio Pisano (ORCID: https://orcid.org/0000-0002-5118-444X)
- Rosario Losiggio (ORCID: https://orcid.org/0009-0001-6181-7976)
- Enrico Tomasi
- Margherita Licheri
- Lian Kah Ti (ORCID: https://orcid.org/0000-0003-0424-286X)
- Nikola Bradić (ORCID: https://orcid.org/0000-0002-7653-1698)
- Gianluca Paternoster (ORCID: https://orcid.org/0000-0002-4032-0821)
- Fabio Guarracino (ORCID: https://orcid.org/0000-0002-2562-0199)
- Andrea Cortegiani (ORCID: https://orcid.org/0000-0003-1416-9993)
- Alberto Zangrillo (ORCID: https://orcid.org/0000-0002-7687-7648)
- Mario Gaudino (ORCID: https://orcid.org/0000-0003-4680-0815)
- Cristina Viscido (ORCID: https://orcid.org/0000-0001-5606-3228)
- Alessandro Pruna (ORCID: https://orcid.org/0009-0006-4588-2037)
- Alessandro Belletti (ORCID: https://orcid.org/0000-0003-3131-0565)
- Domenico Pontillo (ORCID: https://orcid.org/0009-0007-1179-065X)
- Francesco Federici
- Martina Baiardo Redaelli (ORCID: https://orcid.org/0000-0002-4232-1713)
- Rinaldo Bellomo
- Anna Mara Scandroglio
Institutions
- University of Pisa (IT)
- The Royal Melbourne Hospital (AU)
- Vita-Salute San Raffaele University (IT)
- The University of Melbourne (AU)
- Cornell University (US)
- Austin Hospital (AU)
- University Hospital Dubrava (HR)
- Magna Graecia University (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Australian and New Zealand Intensive Care Society (AU)
- IRCCS Policlinico San Donato (IT)
- Ospedale San Carlo (IT)
- University North (HR)
- Department of Medical Sciences (RU)
- CTO Andrea Alesini (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Ospedale Monaldi (IT)
- Ospedale Policlinico San Martino (IT)
- National University Hospital (SG)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Weill Cornell Medicine (US)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Turin (IT)
- Monash University (AU)
- University of Palermo (IT)
Publication Details
- Journal
- Anesthesiology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1097/aln.0000000000005336
- Citations
- 23
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 7.80