Repeated High-dose Fentanyl Administration in Rats Reveals Minimal Tolerance to Unconsciousness, Bradycardia, Muscle Rigidity, and Respiratory Depression
The authors established a rodent model of repeated high-dose fentanyl administration. Overall, significant evidence of tolerance was not observed after 10 exposures of high-dose fentanyl for any of the analyzed parameters. These results suggest that tolerance does not develop for fentanyl-induced unconsciousness, muscle rigidity, or respiratory depression.
Authors
- Ken Solt (ORCID: https://orcid.org/0000-0001-5328-2062)
- Kathleen F. Vincent (ORCID: https://orcid.org/0000-0001-6098-9998)
- David P. Obert (ORCID: https://orcid.org/0000-0002-6746-557X)
- G. Park (ORCID: https://orcid.org/0000-0001-8198-0845)
- David R. Schreier (ORCID: https://orcid.org/0000-0001-6088-2015)
- E. R. Korn (ORCID: https://orcid.org/0009-0000-8899-8108)
- Kaitlyn Strong
- Carla Troyas (ORCID: https://orcid.org/0009-0007-3781-3274)
Institutions
- Brigham Young University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Technical University of Munich (DE)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1097/aln.0000000000005324
- Citations
- 6
- Primary Topic
- Veterinary Pharmacology and Anesthesia
- Type
- article
- Field-Weighted Citation Impact
- 3.83