LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer
LKB1 and Skp2 are required for intact PD-L1 protein expression and TME remodeling in NSCLC. Inhibition of Skp2 resulted in a conversion from "hot" TME to "cold" TME and abrogated therapeutic outcomes of immunotherapy. Screening LKB1 and Skp2 status would be helpful to select recipients who may benefit from anti-PD-1/PD-L1 immunotherapy.
Authors
- Wenjie Yan (ORCID: https://orcid.org/0000-0002-7009-8360)
- Jian Feng (ORCID: https://orcid.org/0000-0003-4248-4237)
- Liting Lv
- Qing Miao (ORCID: https://orcid.org/0000-0002-3125-1238)
- Mingxiang Ye
- Jie Yin (ORCID: https://orcid.org/0000-0003-2611-0112)
- Hongbing Liu (ORCID: https://orcid.org/0000-0002-3411-4597)
- Yong Song (ORCID: https://orcid.org/0000-0003-4979-4131)
- Wei Liu (ORCID: https://orcid.org/0000-0003-0012-6845)
- Peilin Chen (ORCID: https://orcid.org/0000-0003-4154-0487)
- Dong Wang (ORCID: https://orcid.org/0000-0001-7695-8459)
- Jiawen Lv
- Tangfeng Lv (ORCID: https://orcid.org/0009-0003-0987-6770)
- Sutong Zhan
Institutions
- Nantong University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Affiliated Hospital of Nantong University (CN)
- Educational Department of Liaoning Province (CN)
- People's Liberation Army 401 Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009444
- Citations
- 11
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province