Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction
Using two commercially available assays, u-CTX-II differed significantly in terms of both concentration and trends in the first year following ACL reconstruction. The specific assay used is critical to consider when interpreting results and has implications for pooling data and meta-analysis.
Authors
- Andrew F. Hill (ORCID: https://orcid.org/0000-0001-5581-2354)
- Natasha Vassileff (ORCID: https://orcid.org/0000-0001-6554-4496)
- Haydn J. Klemm (ORCID: https://orcid.org/0009-0001-9074-3136)
- Lachlan M. Batty (ORCID: https://orcid.org/0000-0002-3914-1666)
- Brian M. Devitt (ORCID: https://orcid.org/0000-0003-2947-6996)
- Jereme G. Spiers (ORCID: https://orcid.org/0000-0001-5872-8983)
- Julian A. Feller (ORCID: https://orcid.org/0000-0002-5737-4519)
- Kate E. Webster (ORCID: https://orcid.org/0000-0002-5573-3688)
- Timothy S. Whitehead
Institutions
- Australian National University (AU)
- La Trobe University (AU)
- St Vincent's Hospital Melbourne (AU)
- Footscray Hospital (AU)
- Western Health (AU)
- Ansell (Australia) (AU)
- Sports Surgery Clinic (IE)
- Victoria University (AU)
- St Vincents Institute of Medical Research (AU)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.ocarto.2024.100561
- Citations
- 3
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Australian Orthopaedic Association
- Medical Research Council
- National Health and Medical Research Council