Management of febrile neutropenia: consensus of the Brazilian Association of Hematology, Blood Transfusion and Cell Therapy - ABHH
Febrile neutropenia is a major complication of the treatment of patients with hematologic diseases. Recent epidemiologic changes, with an increase in infection caused by drug-resistant bacteria, represent a major challenge for the proper management of febrile neutropenia. The impact of these changes in the epidemiology of infection may vary according to the region. In this document we present recommendations from the Infectious Diseases Committee of the Brazilian Association of Hematology, Blood Transfusion and Cell Therapy (ABHH) for the management of febrile neutropenia in hematologic patients. The consensus was developed by ten experts in the field, using the Delphi methodology. In the document we provide recommendations for the initial workup, prophylaxis, empiric antibiotic and antifungal therapy, modifications in the empiric regimen and criteria for discontinuing antimicrobial therapy.
Authors
- Márcio Nucci (ORCID: https://orcid.org/0000-0003-4867-0014)
- Maria Daniela Bergamasco (ORCID: https://orcid.org/0000-0002-5795-1785)
- Celso Arrais‐Rodrigues (ORCID: https://orcid.org/0000-0002-6395-6849)
- Belinda Pinto Simões (ORCID: https://orcid.org/0000-0003-4508-8934)
- Jéssica Fernandes Ramos (ORCID: https://orcid.org/0000-0002-7023-9514)
- Mariana Guaraná (ORCID: https://orcid.org/0000-0003-0077-4121)
- Clarisse Martins Machado (ORCID: https://orcid.org/0000-0003-1417-0249)
- Marco Aurélio Salvino (ORCID: https://orcid.org/0000-0001-5885-869X)
- Márcia Garnica (ORCID: https://orcid.org/0000-0003-1067-6680)
- Ana Glória
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal da Bahia (BR)
- Universidade de São Paulo (BR)
- Hospital Israelita Albert Einstein (BR)
- Hospital Universitário Gaffrée e Guinle (BR)
- Hospital Amaral Carvalho (BR)
- Hospital Universitário Antônio Pedro (BR)
- Hospital Sírio-Libanês (BR)
- Hospital São Paulo (BR)
Publication Details
- Journal
- Hematology Transfusion and Cell Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.htct.2024.11.119
- Citations
- 3
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.85