Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors associated
Delayed surgical intervention beyond 48 h post-injury in mild-moderate TBI patients results in a significantly increased postoperative inflammatory response, as evidenced by elevated serum levels of TNF-<i>α</i> and IL-6. Neurological deficits, PTS, reduced hemoglobin rate, and extra-axial intracranial hemorrhage are factors associated with this heightened response.
Authors
- Edward Baert (ORCID: https://orcid.org/0000-0002-8409-6366)
- Larrey Kasereka Kamabu (ORCID: https://orcid.org/0000-0003-2046-5617)
- Fredrick Makumbi (ORCID: https://orcid.org/0000-0002-6460-7325)
- Gift Ahimbisibwe
- David Patrick Kateete (ORCID: https://orcid.org/0000-0001-8075-3069)
- Moses Galukande
- Stephen Cose (ORCID: https://orcid.org/0000-0002-5156-037X)
- Hervé Monka Lekuya (ORCID: https://orcid.org/0000-0003-1913-4378)
- Jelle Vandersteene (ORCID: https://orcid.org/0000-0003-0438-5406)
- Marjorie Nakibuule
- Anthony T. Fuller (ORCID: https://orcid.org/0000-0001-8841-6948)
- Geoffrey Olweny
- Jean-Pierre Okito Kalala
- Anthony Kirabira
- Emmanuel Biryabarema
Institutions
- Duke University (US)
- Ghent University Hospital (BE)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fneur.2024.1484742
- Citations
- 4
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Universiteit Gent
- Duke Global Health Institute, Duke University