Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection

Infection of an adult rhesus macaque with SARS-CoV-2 led to viral RNAemia in nose, throat, and lungs. The animal also presented extended fecal shedding of viral genomic and subgenomic messenger RNA and replication-competent virus for more than 3 weeks after infection. Positron emission tomography revealed increased intestinal glucose metabolism which was histologically related to inflammation of the ileum. These findings highlight the potential of the virus to cause gastrointestinal infections in macaques like this is also regularly observed in COVID-19 patients and substantiates the probability of virus transmission via the fecal-oral route. This study further adds the importance of nonhuman primates as a valuable animal model to study SARS-CoV-2 infection in humans.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2024-12-18
DOI
https://doi.org/10.3389/fcimb.2024.1505720
Citations
1
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.39

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article

Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection

Ernst J. Verschoor, Judith M. A. van den Brand, Eric J. Snijder, Marieke A. Stammes et al.
1 citations
Frontiers in Cellular and Infection Microbiology
SARS-CoV-2 and COVID-19 Research
0.39
article

Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection

Ernst J. Verschoor, Judith M. A. van den Brand, Eric J. Snijder, Marieke A. Stammes, Lisette Meijer, Zahra Fagrouch, Ivanela Kondova, Henk Niphuis, Willy Bogers, Babs E. Verstrepen, Gwendoline Kiemenyi Kayere, Kinga P. Böszörményi, Lia van der Hoek, B. Berkhout
article en
1 citations

Abstract

Infection of an adult rhesus macaque with SARS-CoV-2 led to viral RNAemia in nose, throat, and lungs. The animal also presented extended fecal shedding of viral genomic and subgenomic messenger RNA and replication-competent virus for more than 3 weeks after infection. Positron emission tomography revealed increased intestinal glucose metabolism which was histologically related to inflammation of the ileum. These findings highlight the potential of the virus to cause gastrointestinal infections in macaques like this is also regularly observed in COVID-19 patients and substantiates the probability of virus transmission via the fecal-oral route. This study further adds the importance of nonhuman primates as a valuable animal model to study SARS-CoV-2 infection in humans.

Frontiers in Cellular and Infection MicrobiologyVol. 14
Utrecht University (NL), Leiden University Medical Center (NL), Biomedical Primate Research Centre (NL), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Leids Universitair Medisch Centrum
Good health and well-being
Openalex Percentile: Top 34%
SARS-CoV-2 and COVID-19 Research
0.39
DOIOpen Access PDFOpenAlex
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