Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis
Within this study, we showed hypoxia-mediated transcriptome changes characteristic of EuESCs and EcESCs and identified TGFBI as a potential therapeutic target for endometriosis due to its role in fibrosis and angiogenesis.
Authors
- Parameswaran Grace Lalitkumar (ORCID: https://orcid.org/0000-0001-6733-533X)
- Nageswara Rao Boggavarapu (ORCID: https://orcid.org/0000-0002-8588-8445)
- Vijayachitra Modhukur (ORCID: https://orcid.org/0000-0002-7123-9903)
- Kristina Gemzell‐Danielsson (ORCID: https://orcid.org/0000-0001-6516-1444)
- Keiu Kask (ORCID: https://orcid.org/0000-0002-0629-2601)
- Darja Lavõgina (ORCID: https://orcid.org/0000-0001-5167-2817)
- Maire Peters (ORCID: https://orcid.org/0000-0003-2063-242X)
- Andres Salumets (ORCID: https://orcid.org/0000-0002-1251-8160)
- Külli Samuel
- Helle Karro
- Meruert Sarsenova (ORCID: https://orcid.org/0000-0001-9673-732X)
Institutions
- Karolinska University Hospital (SE)
- Tartu University Hospital (EE)
- Karolinska Institutet (SE)
- Competence Centre on Health Technologies (Estonia) (EE)
- University of Tartu (EE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fendo.2024.1465393
- Citations
- 4
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.15