Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis
Although synovitis increases during OA, our findings suggest that exhaustion, dysfunction, and loss of immune-regulatory macrophages is associated with worse pain and may be an important therapeutic target.
Authors
- Tristan Maerz (ORCID: https://orcid.org/0000-0002-4523-6012)
- C. Thomas Appleton (ORCID: https://orcid.org/0000-0001-7148-0767)
- Joseph Daniel Klapak
- Edward M. Vasarhelyi (ORCID: https://orcid.org/0000-0001-9942-9605)
- Benoit Fiset (ORCID: https://orcid.org/0000-0003-0372-8868)
- Garth Blackler (ORCID: https://orcid.org/0009-0009-0651-7055)
- Trevor B. Birmingham (ORCID: https://orcid.org/0000-0002-3300-7677)
- Steven J. MacDonald (ORCID: https://orcid.org/0000-0001-7838-0603)
- Easton C. Farrell (ORCID: https://orcid.org/0009-0008-0339-7951)
- Alexander J. Knights (ORCID: https://orcid.org/0000-0001-8402-2212)
- Brent A. Lanting (ORCID: https://orcid.org/0000-0001-8176-3824)
- Holly T. Philpott (ORCID: https://orcid.org/0000-0002-6146-0241)
- Logan A. Walsh (ORCID: https://orcid.org/0000-0001-8771-2577)
- J. Robert Giffin (ORCID: https://orcid.org/0000-0002-8227-0009)
Institutions
- Western University (CA)
- University of Michigan (US)
- London Health Sciences Centre (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1002/art.43089
- Citations
- 20
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.40
Funders
- Academic Medical Organization of Southwestern Ontario
- Canada Research Chairs
- National Institutes of Health
- Canadian Institutes of Health Research