Hippocampal SIRT1 signaling mediates the ameliorative effect of treadmill exercise on anxiety- and depression-like behavior in APP/PS1 mice
These findings reveal that treadmill exercise reduces anxiety- and depression-like behaviors in six-month-old APP/PS1 mice by enhancing the SIRT1-dependent PGC-1α/NRF1/TFAM axis, promoting mitochondrial biogenesis in the hippocampus.
Authors
- Jingwen Liao (ORCID: https://orcid.org/0000-0002-4438-5577)
- Yumin Jiang (ORCID: https://orcid.org/0009-0009-6375-5703)
- Lianwei Mu (ORCID: https://orcid.org/0000-0001-9453-1045)
- Min Hu (ORCID: https://orcid.org/0009-0004-2376-0157)
- Yarong Wang (ORCID: https://orcid.org/0000-0002-0551-5412)
- Zongbing Zhang
Institutions
- Guangzhou Sport University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fnagi.2024.1489214
- Citations
- 6
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China