Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
These findings underscore the prospect that increased tissue levels of long-chain omega-3 PUFAs, particularly DHA, are favorably associated with SLE outcomes. Although further research is needed to establish causal relationships, existing evidence supports the role of omega-3 PUFAs in managing cardiovascular and chronic kidney disease, common SLE comorbidities. Most study participants exhibited low omega-3 PUFA status, suggesting substantial potential for improvement through targeted dietary interventions and supplementation. This study supports a potential role for precision nutrition in comprehensive SLE management, considering the impact of PUFAs, SFAs and MUFAs.
Authors
- Kristen N. Gilley (ORCID: https://orcid.org/0000-0002-1988-9845)
- Wendy Marder (ORCID: https://orcid.org/0000-0001-7963-4206)
- Jenifer I. Fenton (ORCID: https://orcid.org/0000-0002-8875-3239)
- Kamil E. Barbour (ORCID: https://orcid.org/0000-0003-0546-6742)
- Afton L. Hassett (ORCID: https://orcid.org/0000-0003-2982-484X)
- Emily C. Somers (ORCID: https://orcid.org/0000-0001-5234-3978)
- Raghav Jain (ORCID: https://orcid.org/0000-0002-1284-6762)
- James J. Pestka (ORCID: https://orcid.org/0000-0003-4689-2756)
- Suzanna M. Zick (ORCID: https://orcid.org/0000-0003-0914-4927)
- Kexin Li (ORCID: https://orcid.org/0000-0002-6282-4414)
- Lu Wang (ORCID: https://orcid.org/0000-0002-3134-2519)
- W. Joseph McCune
- Sidney J. Herndon-Fenton
Institutions
- Centers for Disease Control and Prevention (US)
- University of Michigan (US)
- National Center for Chronic Disease Prevention and Health Promotion (US)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1459297
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- U.S. Department of Health and Human Services
- U.S. Department of Agriculture
- Michigan Department of Health and Human Services
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute of Food and Agriculture
- National Institute of Environmental Health Sciences
- National Center for Advancing Translational Sciences