Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease
Together, this study describes a novel protocol that overcomes motivational differences and detects attention and impulsivity deficits in 3xTg-AD mice utilizing the IntelliCage.
Authors
- Ramón Velázquez (ORCID: https://orcid.org/0000-0002-7722-0533)
- Ian M. McDonough (ORCID: https://orcid.org/0000-0003-0907-8931)
- Jessica M. Judd (ORCID: https://orcid.org/0000-0001-9993-6391)
- Wendy Winslow (ORCID: https://orcid.org/0000-0001-9641-4010)
- Faizan Mistry
Institutions
- Alzheimer's Association (US)
- Arizona Alzheimer’s Consortium
- Arizona State University (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fnagi.2024.1466415
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96