Identification of hub programmed cell death-related genes and immune infiltration in Crohn’s disease using bioinformatics
This study identified <i>MMP1</i>, <i>SAA1</i>, and <i>PLAU</i> as hub genes involved in PCD in patients with CD. These genes regulate immune cell function and their expression levels are closely related to immune cell infiltration. These findings provide novel insights into the mechanisms underlying CD pathogenesis. The identified PCD genes and regulatory miRNAs are potential biomarkers and therapeutic targets for CD.
Authors
- Xiang Gao (ORCID: https://orcid.org/0000-0002-8102-2396)
- Kang Chao (ORCID: https://orcid.org/0000-0003-2342-0422)
- Qingfan Yang (ORCID: https://orcid.org/0000-0003-4978-8575)
- Qin Guo (ORCID: https://orcid.org/0000-0001-7515-8193)
- Hailing Liu (ORCID: https://orcid.org/0000-0001-8788-0482)
- Biyao Wang (ORCID: https://orcid.org/0000-0001-8152-7928)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3389/fgene.2024.1425062
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Guangzhou Municipal Science and Technology Project