Exploring the Synergistic Effects of Erinacines on Microglial Regulation and Alzheimer's Pathology Under Metabolic Stress
Our findings demonstrate the dual action of erinacines in modulating microglia morphology and phenotype while providing neuroprotection in a model that closely mimic the complexities of human Alzheimer's disease. Additionally, this study provides the foundation for understanding the potential mechanisms of action of erinacines, highlighting their promise as a novel treatment approach for Alzheimer's, particularly in cases complicated by metabolic dysfunction.
Authors
- Chi‐Ying F. Huang (ORCID: https://orcid.org/0000-0003-4898-4937)
- Chin‐Chu Chen (ORCID: https://orcid.org/0000-0002-5340-6552)
- Young‐Ji Shiao (ORCID: https://orcid.org/0000-0002-2699-116X)
- Li‐Ya Lee
- Wei‐Jan Huang (ORCID: https://orcid.org/0000-0001-9548-5829)
- Wan‐Ping Chen (ORCID: https://orcid.org/0000-0001-9043-4096)
- Anh Thuc Nguyen
- Kuan‐Wei Wu
- Van Thanh Bui (ORCID: https://orcid.org/0009-0005-1296-3968)
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Grape King (Taiwan) (TW)
- National Research Institute of Chinese Medicine (TW)
- Ministry of Health and Welfare (TW)
- Taipei Medical University (TW)
- Academia Sinica (TW)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70137
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Grape King
- National Science and Technology Council