Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the <scp>NTF3</scp>/<scp>PI3K</scp>/<scp>AKT</scp> Pathway
ESK treatment significantly improved functional outcomes and demonstrated neuroprotective effects in animal models of ICH. NTF3/PI3K/AKT pathway activation by ESK indicates its therapeutic potential in the treatment of ICH.
Authors
- Gaiqing Yang
- Qiang Li (ORCID: https://orcid.org/0000-0003-1350-4008)
- Yuanyuan Zheng (ORCID: https://orcid.org/0000-0003-4930-1974)
- Shaoshuai Wang (ORCID: https://orcid.org/0000-0003-0315-7866)
- Xiaoyu Niu
- Jian Wang (ORCID: https://orcid.org/0000-0003-2291-640X)
- Junmin Wang (ORCID: https://orcid.org/0000-0001-9830-0164)
- Xihua Lu (ORCID: https://orcid.org/0000-0001-9033-9363)
- Junyang Wang (ORCID: https://orcid.org/0000-0001-6588-6947)
- Nan Li (ORCID: https://orcid.org/0000-0003-1549-1044)
- Ting C. Zhao (ORCID: https://orcid.org/0000-0001-6376-0275)
- Changsheng Li (ORCID: https://orcid.org/0000-0003-3412-010X)
- Wang Wang (ORCID: https://orcid.org/0000-0001-9400-0949)
- Liwei Zhang
Institutions
- Army Medical University (CN)
- Second Military Medical University (CN)
- Zhengzhou University (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou Central Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou People's Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70145
- Citations
- 6
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation