Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma
Solid predominant histology and high-podoplanin expression in CAFs predicted osimertinib resistance, potentially guiding the selection of patients for more intensive treatments beyond osimertinib monotherapy.
Authors
- Hiroki Izumi (ORCID: https://orcid.org/0000-0002-9566-4859)
- Kiyotaka Yoh
- Hibiki Udagawa (ORCID: https://orcid.org/0000-0001-8822-2684)
- Tetsuya Sakai (ORCID: https://orcid.org/0000-0001-5884-2735)
- Yuji Uehara (ORCID: https://orcid.org/0000-0001-8047-8730)
- Naoya Sakamoto (ORCID: https://orcid.org/0000-0003-0061-059X)
- Shigeki Umemura (ORCID: https://orcid.org/0000-0001-8118-1146)
- Keiju Aokage (ORCID: https://orcid.org/0000-0003-3193-9646)
- Kōichi Goto (ORCID: https://orcid.org/0000-0002-3023-2510)
- Shingo Sakashita (ORCID: https://orcid.org/0000-0003-1133-3313)
- Masahiro Tsuboi
- Genichiro Ishii (ORCID: https://orcid.org/0000-0001-8637-3323)
- Yukio Hosomi (ORCID: https://orcid.org/0000-0002-3849-5905)
- Tetsuro Taki (ORCID: https://orcid.org/0000-0001-8654-6896)
- Eri Sugiyama (ORCID: https://orcid.org/0000-0002-2962-2853)
- Michiko Nagamine (ORCID: https://orcid.org/0000-0001-6765-6117)
- Yoshitaka Zenke (ORCID: https://orcid.org/0000-0002-7641-9065)
- Shingo Matsumoto (ORCID: https://orcid.org/0000-0001-9627-5401)
- Motohiro Kojima (ORCID: https://orcid.org/0000-0002-6150-6545)
- S. Kubota
Institutions
- Tokyo Metropolitan Komagome Hospital (JP)
- National Cancer Center Hospital East (JP)
Publication Details
- Journal
- JTO Clinical and Research Reports
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.jtocrr.2024.100779
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Japan Society for the Promotion of Science