Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents
Adult-derived GRSs for IR are significantly associated with cardiometabolic traits in children and adolescents. If validated in independent study samples, our findings suggest the contribution of adult-based GRSs in assessing IR-related cardiometabolic risk in youth.
Authors
- Yun Huang (ORCID: https://orcid.org/0000-0002-3064-6641)
- Sara Stinson (ORCID: https://orcid.org/0000-0002-1491-9179)
- Rasmus Tanderup Jensen (ORCID: https://orcid.org/0000-0002-4241-3394)
- Larry J. Anderson (ORCID: https://orcid.org/0000-0002-0652-6834)
- Jens‐Christian Holm (ORCID: https://orcid.org/0000-0003-4653-342X)
- Sara Bech Christensen
- Axel Illeris Poggi (ORCID: https://orcid.org/0000-0003-3978-9857)
- Niels Grarup (ORCID: https://orcid.org/0000-0001-5526-1070)
- Oluf Pedersen (ORCID: https://orcid.org/0000-0002-3321-3972)
- Sufyan Suleman (ORCID: https://orcid.org/0000-0001-6612-6915)
- Cilius Esmann Fonvig (ORCID: https://orcid.org/0000-0002-5031-0125)
- Torben Hansen (ORCID: https://orcid.org/0000-0001-8748-3831)
- Maria Martens Fraulund (ORCID: https://orcid.org/0000-0002-0704-815X)
Institutions
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- Aarhus University (DK)
- Novo Nordisk Foundation (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Holbæk Sygehus (DK)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1210/clinem/dgae882
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Novo Nordisk
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Novo Nordisk Fonden
- Novo Nordisk Foundation Center for Basic Metabolic Research