Significance and limitations of routine p16/Ki-67 immunohistochemistry as a diagnostic tool for high-grade squamous intraepithelial lesions of the uterine cervix
p16/Ki-67 IHC significantly improved the diagnostic performance for HSIL. In cases that remain inconclusive after IHC, IHC-based risk stratification offers a valuable approach for surveillance, thus mitigating delays in HSIL diagnosis.
Authors
- Fumi Kawakami (ORCID: https://orcid.org/0000-0002-3242-0988)
- Kazutaka Ozono (ORCID: https://orcid.org/0000-0002-9218-2360)
- Yoshiki Mikami (ORCID: https://orcid.org/0000-0002-5759-6736)
Institutions
- University of the Ryukyus (JP)
- Kumamoto University Hospital (JP)
- Kumamoto Orthopedic Surgery Hospital (JP)
- Kumamoto Medical Center (JP)
Publication Details
- Journal
- Obstetrics & Gynecology Science
- Published
- 2024-12-18
- DOI
- https://doi.org/10.5468/ogs.24236
- Citations
- 2
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77