An open-source software for the simulation of fixational eye movements

Abstract Laser-scanning confocal microscopy of the human cornea acquires in vivo images of corneal tissues with cellular resolution, which offers diagnostic potential for a variety of diseases. However, involuntary fixational eye movements induce motion artefacts that pose a challenge for accurate morphometric analysis and particularly for preceding image data fusion steps. Different image registration algorithms promise to eliminate such artefacts, but objective, quantitative evaluation of the registration results is difficult because of the lack of ground truth data. Simulation approaches offer a possibility to close this gap. Existing open-source software for the simulation of fixational eye movements is currently limited to creating drift movement. The present contribution proposes complementary models for microsaccade and tremor components to provide complete simulated fixational eye movement paths. In addition, it reports results from an extensive examination of different model parameter combinations. It is shown that the microsaccade model is capable of reproducing intermicrosaccade intervals that closely resemble experimental data. A software implementation is provided as open-source Python modules.