Manufacturing of porous polymer films as a basis for the novel cardiovascular implant devices

Abstract For applications in the cardiovascular field, the production of tailored biomaterials such as those required for insulations or patches is a key technology. In this work we were able to manufacture thermoplastic silicone polycarbonate elastomer scaffolds with a porous external surface. The samples were produced using the dip coating process. Pores were created using the salt leaching technique. The complete removal of the salt was verified by Raman microscopy. The absence of solvents was demonstrated by biocompatibility tests using an endothelial cell line. The potential functionality of the system was thus demonstrated. The next step will focus on promoting the adhesion of suitable cells for specific applications.

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Publication Details

Journal
Current Directions in Biomedical Engineering
Published
2024-12-01
DOI
https://doi.org/10.1515/cdbme-2024-2128
Primary Topic
Orthopaedic implants and arthroplasty
Type
article
Field-Weighted Citation Impact
0.00

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article

Manufacturing of porous polymer films as a basis for the novel cardiovascular implant devices

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Current Directions in Biomedical Engineering
Orthopaedic implants and arthroplasty
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Manufacturing of porous polymer films as a basis for the novel cardiovascular implant devices

Valeria Khaimov, Stefan Siewert, Sebastian Kaule, Niels Grabow, Daniela Koper, Klaus-Peter Schmitz, Thomas Reske, Bradley Merryweather
article en

Abstract

Abstract For applications in the cardiovascular field, the production of tailored biomaterials such as those required for insulations or patches is a key technology. In this work we were able to manufacture thermoplastic silicone polycarbonate elastomer scaffolds with a porous external surface. The samples were produced using the dip coating process. Pores were created using the salt leaching technique. The complete removal of the salt was verified by Raman microscopy. The absence of solvents was demonstrated by biocompatibility tests using an endothelial cell line. The potential functionality of the system was thus demonstrated. The next step will focus on promoting the adhesion of suitable cells for specific applications.

Current Directions in Biomedical EngineeringVol. 10(4)
Institute for ImplantTechnology and Biomaterials (DE), University of Rostock (DE)
European Regional Development Fund, European Social Fund
Openalex Percentile: Top 56%
Orthopaedic implants and arthroplasty
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