GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage
Transcription factor GATA1 could activate HSD17B6 to inhibit cisplatin resistance in LUAD through DNA damage, suggesting that GATA1/HSD17B6 axis may be a potential therapeutic target for chemotherapy resistance in LUAD patients.
Authors
- Xiaoguang Shao (ORCID: https://orcid.org/0000-0002-5570-8984)
- Wan Xia
- Jindao Wang
- Xinyan Geng (ORCID: https://orcid.org/0009-0000-1420-5435)
- Huijie Chen (ORCID: https://orcid.org/0009-0002-9157-9320)
- Hei Wan Hou
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
Publication Details
- Journal
- Genes and Environment
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s41021-024-00321-9
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47