IL-20RA is Associated with the Risk of Diabetic Microangiopathy: A Bidirectional Mendelian Randomization Analysis and Clinical Validation
This study highlights the potential role of specific inflammatory cytokines in the development of diabetic microangiopathy (diabetic nephropathy, diabetic retinopathy and diabetic neuropathy). Additionally, IL-20RA emerges as a potential common risk factor for three diabetic microvascular complications. These findings may provide novel insights into early prevention and new therapeutic strategies for diabetic microvascular complications.
Authors
- Yixuan Lin (ORCID: https://orcid.org/0000-0001-5774-4519)
- Zhaohui Fang (ORCID: https://orcid.org/0000-0003-0258-7696)
- Jinju Li (ORCID: https://orcid.org/0009-0009-7487-1953)
- Tingting Wang (ORCID: https://orcid.org/0000-0003-3342-2616)
- Nuobing Ruan
- Hao Yang (ORCID: https://orcid.org/0009-0008-8919-5938)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dmso.s480366
- Citations
- 2
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- National Natural Science Foundation of China